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The Best Science Supported Supplements for Adrenal Health

The Best Science Supported Supplements for Adrenal Health

Poor adrenal gland health can lead to adrenal fatigue during periods of prolonged stress.  When the adrenals become fatigued they may produce too much or too little cortisol which can lead to further stress, anxiety, tiredness, weakness, irritability and brain fog.

Here are the best science supported supplements for adrenal health found in Adrenal Support by Beyond Vita®:

1. Ashwagandha

Ashwagandha (Withania somnifera), also known as Indian winter cherry or Indian ginseng, is a powerful adaptogenic herb with a long history in Indian Ayurvedic medicine.

During periods of high stress the body can make too much cortisol which can increase a person’s stress response. Ashwagandha has been shown to help reduce high cortisol levels as a response to stress and hence reduce a person’s stress response.1,2

In a 2012 study with 64 people with a history of chronic stress, researchers found that ashwagandha supplementation was able to substantially reduce cortisol levels and stress.3 Researchers in another study also found a reduction in cortisol levels in 130 chronically stressed people.4

Ashwagandha can also help elevate cortisol levels that are too low.5

Ashwagandha can help balance the adrenal glands to reduce stress and fatigue.

2. Rhodiola

Rhodiola (Rhodiola rosea), also known as golden root or arctic root, is a herb native the cold regions of Europe and Asia where it is used in traditional herbal medicine. Rhodiola is also considered an adaptogen because it can help the body adapt to stress.

The hypothalamic-pituitary-adrenal (HPA) axis helps to control the body’s stress response including the release of cortisol. Rhodiola has been shown to exert an anti-stress effect on the HPA axis.6

When a person is stressed, their adrenals can produce too much cortisol which can increase their response to stress. Rhodiola has been suggested to have an inhibitory effect on high cortisol levels and studies have shown it can help reduce stress response.7,8

In a randomized double-blind placebo-controlled study, researchers found that in burnout patients with fatigue syndrome rhodiola extract had decreased cortisol response to awakening stress.9

In another study, rhodiola extract was shown to reduce stress induced fatigue in healthy physicians during night shifts.10

Additional studies also support rhodiola reducing fatigue.11,12

Rhodiola can help reduce stress and promote adrenal health.

3. Korean Ginseng

Korean ginseng (Panax ginseng), also known as Chinese ginseng or Asian ginseng, is a plant native to Eastern Asia.

Bioactive compounds from Korean ginseng help inhibit enzymes that block the binding of stress hormones to their receptors. This action can help increase the effectiveness of the adrenal glands by preventing the overproduction of cortisol.13 In addition researchers claim this can help to redistribute the body’s energy reserves.14

Researchers have found that Korean ginseng can help improve stress response by regulating the function of the hypothalamic–pituitary–adrenal axis.15

A 2018 double-blind placebo-controlled trial found that Korean ginseng can reduce the hypothalamic–pituitary–adrenal axis response to stress.16 Researchers in another study claim Korean ginseng can do this by increasing sensitivity in the hypothalamic–pituitary–adrenal axis.17

Korean ginseng may help improve adrenal health by improving the hypothalamic–pituitary–adrenal axis.

4. Siberian Ginseng

Eleuthero (Eleutherococcus senticosus), also known as Siberian ginseng, is a small plant from Northeastern Asia.

During periods of high stress the adrenal glands might become overworked.

Bioactive compounds from eleuthero help inhibit enzymes that catalyze the degradation of stress hormones into inactive compounds. This action can increase the effectiveness of adrenal gland secretions and preventing the overproduction of cortisol.18 In addition, researchers claim this can help to redistribute the body’s energy reserves.19

Eleuthero has also displayed anti-stress properties. This may help prevent the adrenal glands from being overworked during periods of high stress.20

Eleuthero may help prevent the adrenal glands from being overworked.

5. Pantothenic Acid

A deficiency in pantothenic acid may lead to a lower output of adrenal hormones.21 Another study found supplementing with pantothenic acid may increase output.22

Low adrenal hormone production can result in fatigue and a lack of energy.

Pantothenic acid may help increase adrenal hormone production.

6. Vitamin B6

Vitamin B6 may also be able to support the adrenal glands. The pituitary makes a hormone called adrenocorticotropic hormone (ACTH) which stimulates adrenal gland function and when ACTH is secreted vitamin B6 levels are lowered in the adrenal gland.23 This suggests a possible link.

In addition, a study published in the Journal of Endocrinology found that the action of cortisol is diminished in animals with a low level of vitamin B6. Since the adrenals make cortisol, having enough vitamin B6 may help the action of the adrenal glands.24

Vitamin B6 may help support adrenal gland function.

7. Thiamine

A deficiency in thiamine might contribute to a low level of adrenal hormones. In addition it has also been said to be a protective nutrient for the adrenals that can reduce the overproduction of cortisol during high stress times which may cause anxiety.25

Thiamine may help balance the output of adrenal hormones like cortisol.

8. Vitamin B12

Vitamin B12 may help reset a person’s circadian rhythm and normalize cortisol production.26

Vitamin B12 may help normalize cortisol production by the adrenal glands.

9. Omega-3 Fatty Acids

Increased intake of omega-3 fatty acids has been shown to help reduce basal cortisol secretion in a three week randomized, double-blind and placebo-controlled trial.27

In another three week study, researchers reported that omega-3 fatty acids help inhibit the activation of the adrenals and cortisol release during periods of high mental stress.28

Omega-3 fatty acids may help improve adrenal health by preventing elevated cortisol levels.


These are the best science-backed supplements for adrenal gland function and health.*

We recommend Adrenal Support and Antarctic Krill Oil by Beyond Vita®.  They include the best science supported natural ingredients including the ones listed above.
Try our rated Beyond Vita® supplements 100% risk-free with our 90-day satisfaction guarantee. If you are not happy for any reason you will receive a full refund. It's that simple.